Irini A Doytchinova : rechercher sur Z-Library

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Articles (76)
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Quantitative approaches to computational vaccinology

Doytchinova, Irini A, Flower, Darren R

Journal:

Immunology & Cell Biology

Année:

2002

Langue:

english

Fichier:

PDF, 704 KB

english, 2002

Quantitative structure—plasma protein binding relationships of acidic drugs

Zvetanka Zhivkova, Irini Doytchinova

Journal:

Journal of Pharmaceutical Sciences

Année:

2012

Langue:

english

Fichier:

PDF, 244 KB

english, 2012

Identifying candidate subunit vaccines using an alignment-independent method based on principal amino acid properties

Irini A. Doytchinova, Darren R. Flower

Journal:

Vaccine

Année:

2007

Langue:

english

Fichier:

PDF, 317 KB

english, 2007

Novel hits for acetylcholinesterase inhibition derived by docking-based screening on ZINC database

Doytchinova, Irini, Atanasova, Mariyana, Valkova, Iva, Stavrakov, Georgi, Philipova, Irena, Zhivkova, Zvetanka, Zheleva-Dimitrova, Dimitrina, Konstantinov, Spiro, Dimitrov, Ivan

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 1.59 MB

english, 2018

Thiazolyl-N-substituted amides: A group of effective anti-inflammatory agents with potential for local anesthetic properties. Synthesis, biological evaluation, and a QSAR approach

Dimitra Hadjipavlou-Litina, Athina Geronikaki, Remi Mgonzo, Irini Doytchinova

Journal:

Drug Development Research

Année:

1999

Langue:

english

Fichier:

PDF, 177 KB

english, 1999

CoMFA Study on Adenosine A2A Receptor Agonists

Irini Doytchinova, Iva Valkova, Roumiana Natcheva

Journal:

Molecular Informatics

Année:

2001

Langue:

english

Fichier:

PDF, 205 KB

english, 2001

Platinum Complexes with 5-Methyl-5(4-pyridyl)hydantoin and Its 3-Methyl Derivatives: Synthesis and Cytotoxic Activity – Quantitative Structure-Activity Relationships

Adriana Bakalova, Hristo Varbanov, Rossen Buyukliev, Georgi Momekov, Darvin Ivanov, Irini Doytchinova

Journal:

Archiv der Pharmazie

Année:

2011

Langue:

english

Fichier:

PDF, 226 KB

english, 2011

JenPep: A Novel Computational Information Resource for Immunobiology and Vaccinology.

Helen McSparron, Martin J. Blythe, Christianna Zygouri, Irini A. Doytchinova, Darren R. Flower

Journal:

ChemInform

Année:

2003

Fichier:

PDF, 54 KB

2003

Prediction of steady-state volume of distribution of acidic drugs by quantitative structure–pharmacokinetics relationships

Zvetanka Zhivkova, Irini Doytchinova

Journal:

Journal of Pharmaceutical Sciences

Année:

2012

Langue:

english

Fichier:

PDF, 309 KB

english, 2012

Synthesis and antiproliferative activity of benzo[d]isothiazole hydrazones

Paola Vicini, Matteo Incerti, Irini A. Doytchinova, Paolo La Colla, Bernadetta Busonera, Roberta Loddo

Journal:

European Journal of Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 386 KB

english, 2006

Peptide binding to the HLA-DRB1 supertype: A proteochemometrics analysis

Ivan Dimitrov, Panayot Garnev, Darren R. Flower, Irini Doytchinova

Journal:

European Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 789 KB

english, 2010

Synthesis of some new S-triazine based chalcones and their derivatives as potent antimicrobial agents

Anjani Solankee, Kishor Kapadia, Ana Ćirić, Marina Soković, Irini Doytchinova, Athina Geronikaki

Journal:

European Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 215 KB

english, 2010

Hydrazones of 1,2-benzisothiazole hydrazides: synthesis, antimicrobial activity and QSAR investigations

Paola Vicini, Franca Zani, Pietro Cozzini, Irini Doytchinova

Journal:

European Journal of Medicinal Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 250 KB

english, 2002

Reversed-phase high-performance liquid chromatography for evaluating the distribution of pharmaceutical substances in suppository base–phosphate buffer system

Burya Dimitrova, Irini Doytchinova, Margarita Zlatkova

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Année:

2000

Langue:

english

Fichier:

PDF, 127 KB

english, 2000

A comparative molecular similarity indices (CoMSIA) study of peptide binding to the HLA-A3 superfamily

Pingping Guan, Irini A Doytchinova, Darren R Flower

Journal:

Bioorganic & Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 305 KB

english, 2003

Aminothiazole derivatives with antidegenerative activity on cartilage

Anna Maria Panico, Athina Geronikaki, Remi Mgonzo, Venera Cardile, Barbara Gentile, Irini Doytchinova

Journal:

Bioorganic & Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 433 KB

english, 2003

Quantitative online prediction of peptide binding to the major histocompatibility complex

Channa K. Hattotuwagama, Pingping Guan, Irini A. Doytchinova, Christianna Zygouri, Darren R. Flower

Journal:

Journal of Molecular Graphics and Modelling

Année:

2004

Langue:

english

Fichier:

PDF, 164 KB

english, 2004

AntiJen: a quantitative immunology database integrating functional, thermodynamic, kinetic, biophysical, and cellular data

Christopher P Toseland, Debra J Clayton, Helen McSparron, Shelley L Hemsley, Martin J Blythe, Kelly Paine, Irini A Doytchinova, Pingping Guan, Channa K Hattotuwagama, Darren R Flower

Journal:

Immunome Research

Année:

2005

Langue:

english

Fichier:

PDF, 807 KB

english, 2005

Computer aided selection of candidate vaccine antigens

Darren R Flower, Isabel K Macdonald, Kamna Ramakrishnan, Matthew N Davies, Irini A Doytchinova

Journal:

Immunome Research

Année:

2010

Langue:

english

Fichier:

PDF, 1.62 MB

english, 2010

HLA-DP2 binding prediction by molecular dynamics simulations

Irini Doytchinova, Peicho Petkov, Ivan Dimitrov, Mariyana Atanasova, Darren R. Flower

Journal:

Protein Science

Année:

2011

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2011

Physicochemical explanation of peptide binding to HLA-A*0201 major histocompatibility complex: A three-dimensional quantitative structure-activity relationship study

Irini A. Doytchinova, Darren R. Flower

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

2002

Langue:

english

Fichier:

PDF, 963 KB

english, 2002

Towards the chemometric dissection of peptide – HLA-A*0201 binding affinity: comparison of local and global QSAR models

Irini A. Doytchinova, Valerie Walshe, Persephone Borrow, Darren R. Flower

Journal:

Journal of Computer-Aided Molecular Design

Année:

2005

Langue:

english

Fichier:

PDF, 269 KB

english, 2005

2D and 3D QSAR Analysis of Some Valproic Acid Metabolites and Analogues as Anticonvulsant Agents

Tatiana Netzeva, Irini Doytchinova, Roumiana Natcheva

Journal:

Pharmaceutical Research

Année:

2000

Langue:

english

Fichier:

PDF, 283 KB

english, 2000

CoMFA-based comparison of two models of binding site on adenosine A1 receptor

Irini Doytchinova

Journal:

Journal of Computer-Aided Molecular Design

Année:

2001

Langue:

english

Fichier:

PDF, 156 KB

english, 2001

A Comparative Molecular Similarity Index Analysis (CoMSIA) study identifies an HLA-A2 binding supermotif

Irini A. Doytchinova, Darren R. Flower

Journal:

Journal of Computer-Aided Molecular Design

Année:

2002

Langue:

english

Fichier:

PDF, 299 KB

english, 2002

Synthesis, 5-HT1Aand 5-HT2Areceptor affinity and QSAR study of 1-benzhydryl-piperazine derivatives with xanthine moiety at N4

Iva Valkova, Alexander Zlatkov, Krystyna Nędza, Irini Doytchinova

Journal:

Medicinal Chemistry Research

Année:

2012

Langue:

english

Fichier:

PDF, 1.47 MB

english, 2012

Biodegradable cross-linked prodrug of the bronchial dilator Vephylline®. 2. Kinetics and quantum chemical studies on the release mechanism

Georg Heun, Nikolai Lambov, Alexander Zlatkov, Plamen Peikov, Irini Doytchinova, Krasimira Gesheva

Journal:

Journal of Controlled Release

Année:

1999

Langue:

english

Fichier:

PDF, 111 KB

english, 1999

EpiJen: a server for multistep T cell epitope prediction

Irini A Doytchinova, Pingping Guan, Darren R Flower

Journal:

BMC Bioinformatics

Année:

2006

Langue:

english

Fichier:

PDF, 453 KB

english, 2006

VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines

Irini A Doytchinova, Darren R Flower

Journal:

BMC Bioinformatics

Année:

2007

Langue:

english

Fichier:

PDF, 267 KB

english, 2007

Peptide binding prediction for the human class II MHC allele HLA-DP2: a molecular docking approach

Atanas Patronov, Ivan Dimitrov, Darren R Flower, Irini Doytchinova

Journal:

BMC Structural Biology

Année:

2011

Langue:

english

Fichier:

PDF, 702 KB

english, 2011

Class I T-cell epitope prediction: Improvements using a combination of proteasome cleavage, TAP affinity, and MHC binding

Irini A. Doytchinova, Darren R. Flower

Journal:

Molecular Immunology

Année:

2006

Langue:

english

Fichier:

PDF, 270 KB

english, 2006

Quantitative structure–activity relationships and the prediction of MHC supermotifs

Irini A Doytchinova, Pingping Guan, Darren R Flower

Journal:

Methods

Année:

2004

Langue:

english

Fichier:

PDF, 533 KB

english, 2004

Peptide binding to HLA-DP proteins at pH 5.0 and pH 7.0: a quantitative molecular docking study

Patronov, Atanas, Dimitrov, Ivan, Flower, Darren R, Doytchinova, Irini

Journal:

BMC Structural Biology

Année:

2012

Langue:

english

Fichier:

PDF, 708 KB

english, 2012

Analysis of Peptide−Protein Binding Using Amino Acid Descriptors: Prediction and Experimental Verification for Human Histocompatibility Complex HLA-A*0201

Guan, Pingping, Doytchinova, Irini A., Walshe, Valerie A., Borrow, Persephone, Flower, Darren R.

Journal:

Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 139 KB

english, 2005

Predicting Class I Major Histocompatibility Complex (MHC) Binders Using Multivariate Statistics: Comparison of Discriminant Analysis and Multiple Linear Regression

Doytchinova, Irini A., Flower, Darren R.

Journal:

Journal of Chemical Information and Modeling

Année:

2007

Langue:

english

Fichier:

PDF, 44 KB

english, 2007

Additive Method for the Prediction of Protein−Peptide Binding Affinity. Application to the MHC Class I Molecule HLA-A*0201

Doytchinova, Irini A., Blythe, Martin J., Flower, Darren R.

Journal:

Journal of Proteome Research

Année:

2002

Langue:

english

Fichier:

PDF, 159 KB

english, 2002

In Silico Prediction of Peptide Binding Affinity to Class I Mouse Major Histocompatibility Complexes: A Comparative Molecular Similarity Index Analysis (CoMSIA) Study

Hattotuwagama, Channa K., Doytchinova, Irini A., Flower, Darren R.

Journal:

Journal of Chemical Information and Modeling

Année:

2005

Langue:

english

Fichier:

PDF, 629 KB

english, 2005

Toward Prediction of Class II Mouse Major Histocompatibility Complex Peptide Binding Affinity: in Silico Bioinformatic Evaluation Using Partial Least Squares, a Robust Multivariate Statistical Technique

Hattotuwagama, Channa K., Toseland, Christopher P., Guan, Pingping, Taylor, Debra J., Hemsley, Shelley L., Doytchinova, Irini A., Flower, Darren R.

Journal:

Journal of Chemical Information and Modeling

Année:

2006

Langue:

english

Fichier:

PDF, 332 KB

english, 2006

Toward the Quantitative Prediction of T-Cell Epitopes: CoMFA and CoMSIA Studies of Peptides with Affinity for the Class I MHC Molecule HLA-A*0201

Doytchinova, Irini A., Flower, Darren R.

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 319 KB

english, 2001

Modeling the Peptide−T Cell Receptor Interaction by the Comparative Molecular Similarity Indices Analysis−Soft Independent Modeling of Class Analogy Technique

Doytchinova, Irini A., Flower, Darren R.

Journal:

Journal of Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 428 KB

english, 2006

AllerTOP - a server forin silicoprediction of allergens

Ivan Dimitrov, Darren R Flower, Irini Doytchinova

Journal:

BMC Bioinformatics

Année:

2013

Langue:

english

Fichier:

PDF, 215 KB

english, 2013

MHCPred 2.0

Pingping Guan, Channa K. Hattotuwagama, Irini A. Doytchinova…

Journal:

Applied Bioinformatics

Année:

2006

Langue:

english

Fichier:

PDF, 667 KB

english, 2006

Quantitative Structure – Clearance Relationships of Acidic Drugs

Zhivkova, Zvetanka, Doytchinova, Irini

Journal:

Molecular Pharmaceutics

Année:

2013

Langue:

english

Fichier:

PDF, 815 KB

english, 2013

Antimycobacterial activity of chiral aminoalcohols with camphane scaffold

Petkova, Zhanina, Valcheva, Violeta, Momekov, Georgi, Petrov, Petar, Dimitrov, Vladimir, Doytchinova, Irini, Stavrakov, Georgi, Stoyanova, Malinka

Journal:

European Journal of Medicinal Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2014

Novel camphane-based anti-tuberculosis agents with nanomolar activity

Stavrakov, Georgi, Valcheva, Violeta, Philipova, Irena, Doytchinova, Irini

Journal:

European Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 621 KB

english, 2013

Quantitative Prediction of Peptide Binding to HLA-DP1 Protein

Ivanov, Stefan, Dimitrov, Ivan, Doytchinova, Irini

Journal:

IEEE/ACM Transactions on Computational Biology and Bioinformatics

Année:

2013

Langue:

english

Fichier:

PDF, 798 KB

english, 2013

AllerTOP v.2—a server for in silico prediction of allergens

Dimitrov, Ivan, Bangov, Ivan, Flower, Darren R., Doytchinova, Irini

Journal:

Journal of Molecular Modeling

Année:

2014

Langue:

english

Fichier:

PDF, 231 KB

english, 2014

Design of novel camphane-based derivatives with antimycobacterial activity

Stavrakov, Georgi, Valcheva, Violeta, Philipova, Irena, Doytchinova, Irini

Journal:

Journal of Molecular Graphics and Modelling

Année:

2014

Langue:

english

Fichier:

PDF, 211 KB

english, 2014

The HLA-A2-supermotif: a QSAR definitionElectronic supplementary information (ESI) available: matrices for A6802, A0206, A0203, A0202 and A*0201. See http://www.rsc.org/suppdata/ob/b3/b300707c/

Doytchinova, Irini, Flower, Darren

Journal:

Organic & Biomolecular Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 454 KB

english, 2003

New horizons in mouse immunoinformatics: reliable in silico prediction of mouse class I histocompatibility major complex peptide binding affinity

Hattotuwagama, Channa K., Guan, Pingping, Doytchinova, Irini A., Flower, Darren R.

Journal:

Organic & Biomolecular Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 367 KB

english, 2004